... Respiratory Medicine: Research & Publications


Research Activities at Present:

The department has conducted two phase II studies, four phase III studies and 9 phase IV studies. Ongoing projects currently are:

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    		•  "A Randomized double blind, multicentric, parallel-group safety and efficacy study comparing Formoterol-HFA and Formoterol-CFC both delivered by pressurize metered dose inhaler pMDI in patients of Chronic Asthma" (Cipla).
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    		•  "Comparison of the efficacy and safety of one inhalation of symbicort Turbuhaler 160/4.5 ug b.i.d. plus as-needed with two inhalations of seretide TM" (Astra Zeneca).
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    		•  "An open-label study to evaluate the efficacy of four-drug FDC (SCC-4) a new once a day powder formulation containing Rifampicin-450mg, Isoniazid-225mg, Ethambutol-825mg & PZA-1200mg, for sputum conversion by daily administration during the intensive phase in new smear positive patients".


    Completed Research Projects:

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    		•  Mosaic pattern on high resolution CT scan (HRCT) in respiratory diseases
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    		•  Study of pleural fluid ADA, IgG, IgM and pleural biopsy in pleural tuberculosis
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    		•  Study of sleep disorders in patients with interstitial lung diseases
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    		•  Clinical profile and severity of obstructive sleep apnoea syndromes
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    		•  Comparison of HRCT scan with lung biopsy in interstitial lung diseases
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    		•  Study of clinical profile of chronic airway diseases
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    		•  Study of non-invasive ventilation in patients with respiratory failure


    Drug trials:

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    		•  Role of inhaled steroids in bronchiectasis
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    		•  Role of doxycycline in respiratory tract infections
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    		•  Study of amoxycillin with sulbactam versus amoxycillin in patients in COPD exacerbations
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    		•  Role of enzyme Phlogenzyme in patients with pulmonary TB
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    		•  Role of Cromolyn Sodium plus Salbutamol versus salbutamol in patients with mild asthma
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    		•  Role of R Salbutamol in patients of bronchial asthma
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    		•  Study of Ciclesonide a new inhaled steroid in comparison with budesonide in patients with mild to moderate asthma


    Publications:

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    		•  Over 150 publications in various international national indexed journals, consisting of case reports, letter to editor, pictorial CME, original studies, and review articles.
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    		•  Also, booklets on Sleep, PFT, Tuberculosis, and Asthma are being published.
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    		•  Dr. J.M. Joshi has written chapter on "Atelectasis" for API 2002 and on "MDR tuberculosis" for API update.
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    		•  A book written and edited by Dr. J.M. Joshi on Respiratory diseases is awaiting publication.


    Presentations:

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    		•  Dr. J.M. Joshi, Prof. & Head has been giving lectures, organising CME and workshop on various topics throughout the year.
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    		•  She specializes in conducting CME and workshops on sleep disordered breathing, spirometry, spirometry, multi drug resistance tuberculosis airway disorders, management of asthma and COPD, arterial blood gas analysis.

    Paper presented in last one year:

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    		•  "Comparative Prevalence of Chronic Airway disease" in Asian Research Symposium in Rhinology Trans Pacific Allergy and Immunology Society, Nov 04.
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    		•  "Comparative study of inhaled steroids with either LABA or oral bronchodilators" in Asian Research Symposium in Rhinology Trans Pacific Allergy and Immunology Society, Nov 04.
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    		•  "Sleep Disordered Breathing In Children; A Review" in Paediatric Pulmonology Conference, Pulmocon 2004.
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    		•  "Obliterative Bronchiolitis In Children" in Paediatric Pulmonology Conference, Pulmocon 2004.
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    		•  "Peripheral Lymph Node Tuberculosis In Children A Review Of 23 Cases" in Paediatric Pulmonology Conference, Pulmocon 2004.
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    		•  "Reverse Halo Sign" at monthly Chest Meet, KEM Hospital.
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    		•  "Kikuchi Fujimoto's Syndrome" at monthly Chest Meet, KEM Hospital.



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